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apalutamide will lessen the extent or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with drugs which have been CYP3A4 substrates may result in lower exposure to those prescription drugs.If you take codeine as a liquid, it's going to